{"id":25342,"date":"2025-03-12T16:36:41","date_gmt":"2025-03-12T15:36:41","guid":{"rendered":"https:\/\/centroandaluzalfa1.org\/?page_id=25342"},"modified":"2025-05-21T21:23:45","modified_gmt":"2025-05-21T19:23:45","slug":"research-and-training","status":"publish","type":"page","link":"https:\/\/centroandaluzalfa1.org\/en\/research-and-training\/","title":{"rendered":"Research and Training"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"25342\" class=\"elementor elementor-25342\">\n\t\t\t\t<div class=\"elementor-element elementor-element-af83227 e-flex e-con-boxed e-con e-parent\" data-id=\"af83227\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-fbe4efc elementor-widget__width-initial elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"fbe4efc\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Research and Training<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cadf0db elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"cadf0db\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">MEDICAL RESEARCH AND TRAINING<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b8bd028 elementor-widget__width-initial elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"b8bd028\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>In particular, we work to develop different <b>lines of research<\/b> and <b>spread the knowledge<\/b> about the disease.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-157de2f9 e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"157de2f9\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;animation&quot;:&quot;fadeIn&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-66351505 e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"66351505\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;animation&quot;:&quot;fadeIn&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-49712dfe e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"49712dfe\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;fadeIn&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-61edc9f e-con-full e-flex e-con e-child\" data-id=\"61edc9f\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-25d2c65e e-con-full e-flex e-con e-child\" data-id=\"25d2c65e\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-716e894f elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"716e894f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img fetchpriority=\"high\" decoding=\"async\" width=\"600\" height=\"300\" src=\"https:\/\/centroandaluzalfa1.org\/wp-content\/uploads\/2021\/09\/LINEAS-DE-INVESTIGACION-DEFICIT-ALFA-1-ANTITRIPSINA.jpg\" class=\"attachment-full size-full wp-image-5669\" alt=\"\" srcset=\"https:\/\/centroandaluzalfa1.org\/wp-content\/uploads\/2021\/09\/LINEAS-DE-INVESTIGACION-DEFICIT-ALFA-1-ANTITRIPSINA.jpg 600w, https:\/\/centroandaluzalfa1.org\/wp-content\/uploads\/2021\/09\/LINEAS-DE-INVESTIGACION-DEFICIT-ALFA-1-ANTITRIPSINA-300x150.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/figure><div class=\"elementor-image-box-content\"><h3 class=\"elementor-image-box-title\">Research and Training<\/h3><p class=\"elementor-image-box-description\">Absolutely, we create <b>synergies<\/b> with other Research Centers, in this way, it allows us to advance faster thanks to collaboration.<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-138418f2 e-con-full e-flex e-con e-child\" data-id=\"138418f2\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-30cc5456 elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"30cc5456\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img decoding=\"async\" width=\"600\" height=\"300\" src=\"https:\/\/centroandaluzalfa1.org\/wp-content\/uploads\/2021\/09\/PUBLICACIONES-DEFICIT-ALFA-1-ANTITRIPSINA.png\" class=\"attachment-full size-full wp-image-5667\" alt=\"\" srcset=\"https:\/\/centroandaluzalfa1.org\/wp-content\/uploads\/2021\/09\/PUBLICACIONES-DEFICIT-ALFA-1-ANTITRIPSINA.png 600w, https:\/\/centroandaluzalfa1.org\/wp-content\/uploads\/2021\/09\/PUBLICACIONES-DEFICIT-ALFA-1-ANTITRIPSINA-300x150.png 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/figure><div class=\"elementor-image-box-content\"><h3 class=\"elementor-image-box-title\">Publicactions<\/h3><p class=\"elementor-image-box-description\">Besides, we<b> publish and collaborate <\/b>with other professionals to advance research into this disease.<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-22e42720 e-con-full e-flex e-con e-child\" data-id=\"22e42720\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2b5d8560 elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"2b5d8560\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img decoding=\"async\" width=\"600\" height=\"300\" src=\"https:\/\/centroandaluzalfa1.org\/wp-content\/uploads\/2025\/02\/CURSO-DAAT-CONGRESO.png\" class=\"attachment-full size-full wp-image-24831\" alt=\"\" \/><\/figure><div class=\"elementor-image-box-content\"><h3 class=\"elementor-image-box-title\">Training and Teaching<\/h3><p class=\"elementor-image-box-description\">Also, we <b>train the professionals of today and tomorrow<\/b> so that our community can grow and continue to advance.<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-4983a8a e-flex e-con-boxed e-con e-parent\" data-id=\"4983a8a\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-e95a9e0 e-con-full e-flex e-con e-child\" data-id=\"e95a9e0\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-760b0d1 elementor-widget elementor-widget-heading\" data-id=\"760b0d1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">RESEARCH AND TRAINING<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-120699c elementor-icon-list--layout-traditional elementor-list-item-link-full_width elementor-widget elementor-widget-icon-list\" data-id=\"120699c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-list.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul class=\"elementor-icon-list-items\">\n\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">WE ARE IN CONSTANT EVOLUTION<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d9842d7 elementor-widget elementor-widget-text-editor\" data-id=\"d9842d7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><em>&#8220;We are committed to research&#8221;<\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7d98656 elementor-widget elementor-widget-text-editor\" data-id=\"7d98656\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>We are a group of professionals involved in the <strong>research of Alpha 1 Antitrypsin Deficiency<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6e4ad59 e-con-full e-flex e-con e-child\" data-id=\"6e4ad59\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3c38157 elementor-widget elementor-widget-counter\" data-id=\"3c38157\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"counter.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-counter\">\n\t\t\t<div class=\"elementor-counter-title\">CASES STUDIED<\/div>\t\t\t<div class=\"elementor-counter-number-wrapper\">\n\t\t\t\t<span class=\"elementor-counter-number-prefix\">+<\/span>\n\t\t\t\t<span class=\"elementor-counter-number\" data-duration=\"2000\" data-to-value=\"120000\" data-from-value=\"0\" data-delimiter=\",\">0<\/span>\n\t\t\t\t<span class=\"elementor-counter-number-suffix\"><\/span>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-319433e elementor-widget elementor-widget-counter\" data-id=\"319433e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"counter.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-counter\">\n\t\t\t<div class=\"elementor-counter-title\">PROFESSIONALS<\/div>\t\t\t<div class=\"elementor-counter-number-wrapper\">\n\t\t\t\t<span class=\"elementor-counter-number-prefix\">+<\/span>\n\t\t\t\t<span class=\"elementor-counter-number\" data-duration=\"2000\" data-to-value=\"1000\" data-from-value=\"0\" data-delimiter=\",\">0<\/span>\n\t\t\t\t<span class=\"elementor-counter-number-suffix\"><\/span>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6f3180c e-flex e-con-boxed e-con e-parent\" data-id=\"6f3180c\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-0430937 e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"0430937\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;fadeIn&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-e119746 e-con-full e-flex e-con e-child\" data-id=\"e119746\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ea6d561 elementor-widget elementor-widget-image\" data-id=\"ea6d561\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"300\" src=\"https:\/\/centroandaluzalfa1.org\/wp-content\/uploads\/2021\/09\/INVESTIGACION-DAAT.png\" class=\"attachment-large size-large wp-image-5546\" alt=\"\" srcset=\"https:\/\/centroandaluzalfa1.org\/wp-content\/uploads\/2021\/09\/INVESTIGACION-DAAT.png 600w, https:\/\/centroandaluzalfa1.org\/wp-content\/uploads\/2021\/09\/INVESTIGACION-DAAT-300x150.png 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c1ec479 elementor-widget elementor-widget-heading\" data-id=\"c1ec479\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Basic Research<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e7b0719 elementor-widget elementor-widget-text-editor\" data-id=\"e7b0719\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Our mission is to determine serum alpha-1 antitrypsin concentrations using nephelometry.<\/strong><\/p><p>In addition, we can identify the genotype of various genetic variants in dried blood spots, oral mucosal smears, or whole blood using sequencing techniques or real-time PCR.<\/p><p>Furthermore, we participate in networked research studies with the Carlos III Health Institute (<a href=\"https:\/\/www.isciii.es\/\" target=\"_blank\" rel=\"noopener\">ISCIII<\/a>), the Valencia Clinical Research Institute (<a href=\"https:\/\/www.incliva.es\/\" target=\"_blank\" rel=\"noopener\">INCLIVA<\/a>), and Prog\u00e9nika Biopharma (<a href=\"https:\/\/www.grifols.com\/es\/home\" target=\"_blank\" rel=\"noopener\">GRIFOLS Group<\/a>).<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-216f380 e-con-full e-flex e-con e-child\" data-id=\"216f380\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7c64997 elementor-widget elementor-widget-image\" data-id=\"7c64997\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"300\" src=\"https:\/\/centroandaluzalfa1.org\/wp-content\/uploads\/2021\/09\/ASISTENCIA-A-PACIENTES-CON-DAAT.png\" class=\"attachment-large size-large wp-image-5540\" alt=\"\" srcset=\"https:\/\/centroandaluzalfa1.org\/wp-content\/uploads\/2021\/09\/ASISTENCIA-A-PACIENTES-CON-DAAT.png 600w, https:\/\/centroandaluzalfa1.org\/wp-content\/uploads\/2021\/09\/ASISTENCIA-A-PACIENTES-CON-DAAT-300x150.png 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4b718a2 elementor-widget elementor-widget-heading\" data-id=\"4b718a2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Clinical Research<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ea997fb elementor-widget elementor-widget-text-editor\" data-id=\"ea997fb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>The Centers of Excellence in AATD in Granada, Seville, Galicia, Madrid, and Catalonia conduct clinical studies online.<\/p><p>Thus, together, we evaluate the impact of AATD on the quality of life of patients and their families.<\/p><p><strong>We also assess the effects of treatment on disease progression.<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-333a1a4 e-flex e-con-boxed e-con e-parent\" data-id=\"333a1a4\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;animation&quot;:&quot;none&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ef93baa elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"ef93baa\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Research and Training<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a883ca6 elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"a883ca6\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">PROJECTS<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-41b2920 elementor-icon-list--layout-traditional elementor-list-item-link-full_width elementor-invisible elementor-widget elementor-widget-icon-list\" data-id=\"41b2920\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"icon-list.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul class=\"elementor-icon-list-items\">\n\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"http:\/\/www.centroandaluzalfa1.org\/en\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-far-bookmark\" viewBox=\"0 0 384 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M336 0H48C21.49 0 0 21.49 0 48v464l192-112 192 112V48c0-26.51-21.49-48-48-48zm0 428.43l-144-84-144 84V54a6 6 0 0 1 6-6h276c3.314 0 6 2.683 6 5.996V428.43z\"><\/path><\/svg>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">LINES OF RESEARCH<\/span>\n\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ca4f3c6 e-flex e-con-boxed e-con e-parent\" data-id=\"ca4f3c6\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;,&quot;animation&quot;:&quot;none&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b3c417c elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"b3c417c\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>01.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-acfbc65 elementor-widget elementor-widget-text-editor\" data-id=\"acfbc65\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>To begin, we examine the involvement of microRNAs in the regulation of the serpin-1 antitrypsin gene and their role in alpha-1 antitrypsin deficiency.<br \/><strong>Principal Investigator: Francisco Casas Maldonado.<\/strong><br \/>This multicenter study was conducted at the Carlos III Health Institute of Madrid (ISCIII).<br \/>In short, AATD is a hereditary disorder caused by mutations in the SERPINA1 gene.<\/p><p>Therefore, this disease exhibits a <strong>high degree of variability in clinical manifestations<\/strong>, suggesting that unknown genetic factors may influence disease severity.<\/p><p>Finally, given that microRNAs (miRNAs) are implicated in the pathogenesis of several human diseases, we investigated whether the SERPINA1 gene could be regulated by miRNAs.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4e1e799 elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"4e1e799\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Objetives<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-579b691 elementor-widget elementor-widget-text-editor\" data-id=\"579b691\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ol><li>Initially, we identified the <strong>miRNAs involved<\/strong> in the regulation of the AAT gene.<\/li><li>In addition, we investigated the role of miRNAs as biomarkers in patients with AATD by <strong>performing expression<\/strong> profiling in blood and serum.<\/li><\/ol>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-76fa370 elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"76fa370\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>02.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-94ac77d elementor-widget elementor-widget-text-editor\" data-id=\"94ac77d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>In general, we focused on studying the effect of hypoxia on degranulation, cytokine production, and the oxidative profile of neutrophils in patients with alpha-1 antitrypsin deficiency (AATD).<br \/><b>P<\/b><strong>rincipal Investigator: Amparo Escribano Montaner.<\/strong><br \/><strong>Collaborating Investigator: Francisco Casas Maldonado.<\/strong><br \/>Specifically, we conducted a multicenter study at the Valencia Health Research Institute (INCLIVA).<\/p><p>Thus, the number of neutrophils in the lungs of patients with AATD is significantly higher than in healthy individuals, which could contribute to increased proteolytic activity and hypoxia-induced inflammation, and to the development of COPD observed in some of the patients.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8a9344d elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"8a9344d\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Objetives<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d674af1 elementor-widget elementor-widget-text-editor\" data-id=\"d674af1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ol><li>First, we determined whether <strong>hypoxia<\/strong> induces neutrophil activation in patients with AATD and whether intravenous AAT treatment reduces this activation.<\/li><li>Subsequently, we determined whether there were differences in <strong>neutrophil degranulation<\/strong>, pro-inflammatory cytokine production, and reactive oxygen species (ROS) production in healthy volunteers, patients with AATD, and patients with COPD not associated with AATD under normoxic vs. hypoxic conditions.<\/li><li>The next step was to <strong>analyze the differences between the various phenotypes<\/strong> within patients with AATD.<\/li><li>Finally, we evaluated<strong> the effect of intravenous AAT therapy on neutrophil degranulation<\/strong>, pro-inflammatory cytokine production, and ROS production.<\/li><\/ol>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-210903c elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"210903c\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>03.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-42b284d elementor-widget elementor-widget-text-editor\" data-id=\"42b284d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>We also analyzed parameters of oxidative stress, mitochondrial function, telomere length, and the profile of circulating miRNAs in patients with alpha-1 antitrypsin deficiency. Prognostic implications.<br \/><strong>Principal Investigator: Francisco Dasi Fern\u00e1ndez<\/strong><br \/><strong>Collaborating Investigator: Francisco Casas Maldonado<\/strong><br \/>Specifically, this multicenter study is being conducted at the Valencia Health Research Institute (INCLIVA).<\/p><p>In conclusion, oxidative stress (OS) has been shown to be a factor contributing to the development of liver and lung damage in animal models of AATD.<br \/>Previous studies have shown that OS is implicated in AATD and is associated with the risk of developing lung and\/or liver disease.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3dfb248 elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"3dfb248\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Objetives<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3183fee elementor-widget elementor-widget-text-editor\" data-id=\"3183fee\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ol><li>Initially, we characterized reactive oxygen species (ROS) generated in the <strong>immune system cells<\/strong> of patients with AATD using flow cytometry.<\/li><li>After this, is to <strong>evaluate their mitochondrial function<\/strong> as a potential source of ROS.<\/li><li>Next, we determined telomere length in patients with AATD using qPCR.<br \/>Their <strong>relationship with the severity of lung<\/strong> and\/or liver disease was also studied.<\/li><li>Finally, we <strong>examined the expression profile of circulating miRNAs<\/strong> in patients with AATD using Affymetrix microarrays to determine their prognostic value.<\/li><\/ol>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-e7d725c e-flex e-con-boxed e-con e-parent\" data-id=\"e7d725c\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3022d57 elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"3022d57\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">PUBLICATIONS<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ec788b6 elementor-icon-list--layout-traditional elementor-list-item-link-full_width elementor-invisible elementor-widget elementor-widget-icon-list\" data-id=\"ec788b6\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"icon-list.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul class=\"elementor-icon-list-items\">\n\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"http:\/\/www.centroandaluzalfa1.org\/en\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-far-bookmark\" viewBox=\"0 0 384 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M336 0H48C21.49 0 0 21.49 0 48v464l192-112 192 112V48c0-26.51-21.49-48-48-48zm0 428.43l-144-84-144 84V54a6 6 0 0 1 6-6h276c3.314 0 6 2.683 6 5.996V428.43z\"><\/path><\/svg>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">knowledge is our legacy<\/span>\n\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1916ff9d e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"1916ff9d\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;fadeIn&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-277ec2bf e-con-full e-flex e-con e-child\" data-id=\"277ec2bf\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-49e422b1 elementor-widget elementor-widget-heading\" data-id=\"49e422b1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">01.<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e2ffce elementor-widget elementor-widget-text-editor\" data-id=\"e2ffce\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/drive.google.com\/file\/d\/1-E8IFM9NChF2x-oaB9-yCslzDd-a4PZi\/view\" target=\"_blank\" rel=\"noopener\">Diagnostic and therapeutic approach to AATD from Primary Care.<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5997a931 elementor-widget elementor-widget-heading\" data-id=\"5997a931\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">02.<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-35cc43d1 elementor-widget elementor-widget-text-editor\" data-id=\"35cc43d1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/drive.google.com\/file\/d\/1z_1mPn0CK1KvA2z7L1gHw_Sybqe9U-aV\/view\" target=\"_blank\" rel=\"noopener\">Guide for families of children with AATD (Respira Foundation).<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3efed89d elementor-widget elementor-widget-heading\" data-id=\"3efed89d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">03.<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-45d1b5ea elementor-widget elementor-widget-text-editor\" data-id=\"45d1b5ea\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/www.archbronconeumol.org\/es-pdf-X0300289618626682\" target=\"_blank\" rel=\"noopener\">Importance of genetic diagnosis in patients with AATD.<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4d67cf64 elementor-widget elementor-widget-heading\" data-id=\"4d67cf64\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">04.<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3a7591e5 elementor-widget elementor-widget-text-editor\" data-id=\"3a7591e5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/drive.google.com\/file\/d\/1YK9haVkz5KyURsToc71xerGo8s13GBpU\/view\" target=\"_blank\" rel=\"noopener\">Guide for patients with AATD (Respira Foundation).<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4b25d24 elementor-widget elementor-widget-heading\" data-id=\"4b25d24\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">05.<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2e6f4d7 elementor-widget elementor-widget-text-editor\" data-id=\"2e6f4d7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/drive.google.com\/file\/d\/19vvZVIVI6xkBQ3JpwIiPgGKX0d0R-0FR\/view\" target=\"_blank\" rel=\"noopener\">Manual of Pulmonology and Thoracic Surgery.<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7581f235 elementor-widget elementor-widget-heading\" data-id=\"7581f235\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">06.<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5b2d223 elementor-widget elementor-widget-text-editor\" data-id=\"5b2d223\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5473482\/pdf\/copd-12-1683.pdf\" target=\"_blank\" rel=\"noopener\">Alpha-1 Antitrypsin Pi*SZ genotype: estimated prevalence and number of SZ subjects worldwide.<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4b4d7d3b elementor-widget elementor-widget-heading\" data-id=\"4b4d7d3b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">07.<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5b06e5e2 elementor-widget elementor-widget-text-editor\" data-id=\"5b06e5e2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5743112\/pdf\/copd-13-057.pdf\" target=\"_blank\" rel=\"noopener\">Geographic distribution of COPD prevalence in Europe, estimated using an inverse distance weighting interpolation technique.<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7128a716 elementor-widget elementor-widget-heading\" data-id=\"7128a716\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">08.<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5119b93a elementor-widget elementor-widget-text-editor\" data-id=\"5119b93a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/www.archbronconeumol.org\/es-pdf-S0300289616301247\" target=\"_blank\" rel=\"noopener\">Spanish Registry of Patients with AATD: Database Evaluation and Population Analysis.<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-128bb74b elementor-widget elementor-widget-heading\" data-id=\"128bb74b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">09.<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6aa488b1 elementor-widget elementor-widget-text-editor\" data-id=\"6aa488b1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5315200\/pdf\/copd-12-561.pdf\" target=\"_blank\" rel=\"noopener\">Frequency of the alpha-1 antitrypsin gene Pi*Z and the number of Pi*ZZ genotypes worldwide: an update.<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1071409e elementor-widget elementor-widget-heading\" data-id=\"1071409e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">10.<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2028f65e elementor-widget elementor-widget-text-editor\" data-id=\"2028f65e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/www.neumosur.net\/files\/publicaciones\/Revistas\/2017\/comunicaciones-revista2017v29n1.pdf\" target=\"_blank\" rel=\"noopener\">Spanish Registry of patients with AATD: Evolution from 2005 to 2016 in Andalusia.<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-67e98d20 elementor-widget elementor-widget-heading\" data-id=\"67e98d20\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">11.<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-55a0f394 elementor-widget elementor-widget-text-editor\" data-id=\"55a0f394\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/www.archbronconeumol.org\/es-pdf-X0300289617610785\" target=\"_blank\" rel=\"noopener\">miRNA320c is expressed in patients with AATD and could be a biomarker of lung disease.<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-76005821 e-con-full e-flex e-con e-child\" data-id=\"76005821\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-13e2f87e elementor-widget elementor-widget-heading\" data-id=\"13e2f87e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">12.<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fd37e02 elementor-widget elementor-widget-text-editor\" data-id=\"fd37e02\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/www.archbronconeumol.org\/es-pdf-X0300289617610785\" target=\"_blank\" rel=\"noopener\">Identification of miRNAs that regulate the AAT gene.<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1d2a900a elementor-widget elementor-widget-heading\" data-id=\"1d2a900a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">13.<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-10c925f5 elementor-widget elementor-widget-text-editor\" data-id=\"10c925f5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/www.archbronconeumol.org\/es-pdf-X0300289617610785\" target=\"_blank\" rel=\"noopener\">Evolution of the Spanish Registry of Patients with AATD from 2010 to 2016.<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-baf8904 elementor-widget elementor-widget-heading\" data-id=\"baf8904\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">14.<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-46525c41 elementor-widget elementor-widget-text-editor\" data-id=\"46525c41\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/www.archbronconeumol.org\/es-pdf-X0300289617610785\" target=\"_blank\" rel=\"noopener\">PI*Z allele frequency, PI*ZZ prevalence and estimated number of PI*ZZ subjects in Europe.<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-66804b7d elementor-widget elementor-widget-heading\" data-id=\"66804b7d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">15.<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4dae30fa elementor-widget elementor-widget-text-editor\" data-id=\"4dae30fa\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7857711\/\" target=\"_blank\" rel=\"noopener\">Neutrophil elastase gene expression and relationship with lung function in patients with AATD.<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4e16b6cc elementor-widget elementor-widget-heading\" data-id=\"4e16b6cc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">16.<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-26e6698 elementor-widget elementor-widget-text-editor\" data-id=\"26e6698\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27390278\/\" target=\"_blank\" rel=\"noopener\">Accelerated telomere shortening in children and adolescents with AATD.<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4c303246 elementor-widget elementor-widget-heading\" data-id=\"4c303246\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">17.<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6b29e9ea elementor-widget elementor-widget-text-editor\" data-id=\"6b29e9ea\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/www.archbronconeumol.org\/es-pdf-S030028961400221X\" target=\"_blank\" rel=\"noopener\">Update on indications for active case finding and treatment with intravenous AAT in patients with COPD associated with AATD.<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-382dab45 elementor-widget elementor-widget-heading\" data-id=\"382dab45\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">18.<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-74ddb8a9 elementor-widget elementor-widget-text-editor\" data-id=\"74ddb8a9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/www.archbronconeumol.org\/es-pdf-S0300289611002122\" target=\"_blank\" rel=\"noopener\">Factors associated with the evolution of lung function in patients with AATD from the Spanish registry.<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1a939817 elementor-widget elementor-widget-heading\" data-id=\"1a939817\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">19.<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-68f49d05 elementor-widget elementor-widget-text-editor\" data-id=\"68f49d05\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1753465812438387\" target=\"_blank\" rel=\"noopener\">Reduction of severe exacerbations and hospitalization costs in patients treated with intravenous AAT.<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6fa8ef98 elementor-widget elementor-widget-heading\" data-id=\"6fa8ef98\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">20.<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3cb99772 elementor-widget elementor-widget-text-editor\" data-id=\"3cb99772\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/drive.google.com\/file\/d\/1ZErqdX7bbtBjTfotMBQK-7-DqppEZbae\/view\" target=\"_blank\" rel=\"noopener\">Diagnosis and treatment of AATD.<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6e234319 elementor-widget elementor-widget-heading\" data-id=\"6e234319\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">21.<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e9e8e5 elementor-widget elementor-widget-text-editor\" data-id=\"e9e8e5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/drive.google.com\/file\/d\/1kwzkSVGdJJP9Av0Qy-vdMQCnawa0s_9k\/view\" target=\"_blank\" rel=\"noopener\">Detection and identification of AATD (Alpha one Foundation).<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-633edaa6 elementor-widget elementor-widget-heading\" data-id=\"633edaa6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">22.<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7a1f0090 elementor-widget elementor-widget-text-editor\" data-id=\"7a1f0090\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5870637\/pdf\/copd-13-1001.pdf\" target=\"_blank\" rel=\"noopener\">Long-term evolution of lung function in individuals with AATD from the Spanish registry (REDAAT).<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-4e1ab47f e-con-full e-flex e-con e-child\" data-id=\"4e1ab47f\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2326cb0 elementor-widget elementor-widget-heading\" data-id=\"2326cb0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">23.<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-659186a7 elementor-widget elementor-widget-text-editor\" data-id=\"659186a7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6042212\/pdf\/13023_2018_Article_856.pdf\" target=\"_blank\" rel=\"noopener\">Outstanding issues and future direction.<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5b77ce63 elementor-widget elementor-widget-heading\" data-id=\"5b77ce63\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">24.<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1d8e5bc0 elementor-widget elementor-widget-text-editor\" data-id=\"1d8e5bc0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/drive.google.com\/file\/d\/1mFed8NkcQcPG9KDzOnW4QY4Dk4xNI4fi\/view\" target=\"_blank\" rel=\"noopener\">Pathophysiology, Related Diseases, Diagnosis, and Treatment. 2nd Edition (2016).<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-20888e5c elementor-widget elementor-widget-heading\" data-id=\"20888e5c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">25.<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-30fad3a0 elementor-widget elementor-widget-text-editor\" data-id=\"30fad3a0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7049712\/pdf\/00181-2019.pdf\" target=\"_blank\" rel=\"noopener\">Protocol for the EARCO registry: a pan-European observational study in patients with AATD.<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4658fdd8 elementor-widget elementor-widget-heading\" data-id=\"4658fdd8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">26.<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4add8e36 elementor-widget elementor-widget-text-editor\" data-id=\"4add8e36\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6811757\/pdf\/10.1177_1479973119881777.pdf\" target=\"_blank\" rel=\"noopener\">The importance of patient registries in lung diseases.<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-30afb4a3 elementor-widget elementor-widget-heading\" data-id=\"30afb4a3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">27.<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5587fe7d elementor-widget elementor-widget-text-editor\" data-id=\"5587fe7d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5797472\/pdf\/copd-13-419.pdf\" target=\"_blank\" rel=\"noopener\">AAT in the treatment of lung disease in AATD: clinical implications.<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-24d6fba1 elementor-widget elementor-widget-heading\" data-id=\"24d6fba1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">28.<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6bfff8d8 elementor-widget elementor-widget-text-editor\" data-id=\"6bfff8d8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6023216\/pdf\/pone.0198777.pdf\" target=\"_blank\" rel=\"noopener\">EPOCONSUL Study: Care according to risk level and its adaptation to the Spanish COPD guidelines.<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2f3f5fdb elementor-widget elementor-widget-heading\" data-id=\"2f3f5fdb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">29.<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5654d122 elementor-widget elementor-widget-text-editor\" data-id=\"5654d122\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/www.archbronconeumol.org\/es-existen-diferencias-entre-tratamientos-disponibles-articulo-S0300289618300218?referer=buscador\" target=\"_blank\" rel=\"noopener\">Are there differences between the treatments available for AATD emphysema?<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-224fdaeb elementor-widget elementor-widget-heading\" data-id=\"224fdaeb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">30.<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-386650b9 elementor-widget elementor-widget-text-editor\" data-id=\"386650b9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5910458\/pdf\/12325_2018_Article_690.pdf\" target=\"_blank\" rel=\"noopener\">Impact of a health management program on healthcare outcomes for patients receiving intravenous AAT treatment.<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-378823d4 elementor-widget elementor-widget-heading\" data-id=\"378823d4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">31.<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1bbb4f9b elementor-widget elementor-widget-text-editor\" data-id=\"1bbb4f9b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29191952\/\" target=\"_blank\" rel=\"noopener\">European Respiratory Society statement: diagnosis and treatment of AATD lung disease.<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4b24282a elementor-widget elementor-widget-heading\" data-id=\"4b24282a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">32.<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3b3d7b62 elementor-widget elementor-widget-text-editor\" data-id=\"3b3d7b62\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4848857\/pdf\/12890_2016_Article_222.pdf\" target=\"_blank\" rel=\"noopener\">Knowledge about the diagnosis and treatment of AATD in Spain and Portugal.<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-76bfa257 elementor-widget elementor-widget-heading\" data-id=\"76bfa257\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">33.<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1584a5b7 elementor-widget elementor-widget-text-editor\" data-id=\"1584a5b7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S1138359316300892?via%3Dihub\" target=\"_blank\" rel=\"noopener\">Detection of AATD: study in patients with COPD diagnosed in Primary Care.<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Research and Training MEDICAL RESEARCH AND TRAINING In particular, we work to develop different lines of research and spread the knowledge about the disease. Research and Training Absolutely, we create synergies with other Research Centers, in this way, it allows us to advance faster thanks to collaboration. Publicactions Besides, we publish and collaborate with other [&hellip;]<\/p>\n","protected":false},"author":5,"featured_media":8126,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"full-width-container","site-content-style":"unboxed","site-sidebar-style":"unboxed","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-25342","page","type-page","status-publish","has-post-thumbnail","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - 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