{"id":4200,"date":"2020-07-22T11:53:19","date_gmt":"2020-07-22T09:53:19","guid":{"rendered":"https:\/\/centroandaluzalfa1.org\/?p=4200"},"modified":"2020-07-22T11:59:37","modified_gmt":"2020-07-22T09:59:37","slug":"liver-and-aatd","status":"publish","type":"post","link":"https:\/\/centroandaluzalfa1.org\/en\/liver-and-aatd\/","title":{"rendered":"Liver Involvement in mild Alpha-1 Antitrypsin Deficiency"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"4200\" class=\"elementor elementor-4200\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-87a5972 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"87a5972\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-4dc77a4\" data-id=\"4dc77a4\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-245245e elementor-widget elementor-widget-text-editor\" data-id=\"245245e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong><span style=\"color: #333333; font-family: Lato, Helvetica, sans-serif; background-color: #ffffff;\">Published in \u201cGa<i>stroenterology\u201d<\/i><\/span><\/strong><span style=\"color: #333333;\"><strong><i><br \/><\/i><\/strong><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7e8d400 elementor-widget elementor-widget-text-editor\" data-id=\"7e8d400\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #00635b;\"><strong>The Alpha1-Liver Team from Aachen, Germany, which coordinates the European study group for alpha1-antitrypsin deficiency-related liver disease, has published the latest results on liver involvement in mild alpha1-antitrypsin deficiency in the renowned journal Gastroenterology. This work appears a year after the contribution that focused on the liver phenotype in severe alpha1-antitrypsin deficiency and was also published in Gastroenterology.<\/strong><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-fdd17f1 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"fdd17f1\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-8976248\" data-id=\"8976248\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f539687 elementor-widget elementor-widget-image\" data-id=\"f539687\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"300\" height=\"144\" src=\"https:\/\/centroandaluzalfa1.org\/wp-content\/uploads\/2020\/07\/serv_centrales_portada-300x144-1.jpg\" class=\"attachment-large size-large wp-image-4193\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-508e404\" data-id=\"508e404\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8bf5f32 elementor-widget elementor-widget-text-editor\" data-id=\"8bf5f32\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"background-color: #ffffff;\"><span style=\"color: #00635b;\"><span style=\"font-weight: bold;\">To further information click here:\u00a0<a style=\"color: #00635b;\" href=\"http:\/\/www.alpha1-liver.eu\/\" target=\"_blank\" rel=\"noopener\">www.alpha1-liver.eu<\/a><\/span><\/span><\/p><p style=\"background-color: #ffffff;\">Review of alpha1-antitrypsin deficiency by Prof. Strnad in the New England Journal of Medicine.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-43f3cac elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"43f3cac\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-46150b0\" data-id=\"46150b0\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3e1ef21 elementor-widget elementor-widget-button\" data-id=\"3e1ef21\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMra1910234\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Read more<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-6eab6b6 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6eab6b6\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-eceb90b\" data-id=\"eceb90b\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f99ff8f elementor-widget elementor-widget-text-editor\" data-id=\"f99ff8f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"background-color: #ffffff;\"><b>Publication: <\/b>Schneider CV*, Hamesch K*, Gross A, Mandorfer M, Moeller LS, Pereira V, Pons M, Kuca P, Reichert MC, Benini F, Burbaum B, Voss J, Gutberlet M, Woditsch V, Lindhauer C, Fromme M, K\u00fcmpers J, Bewersdorf L, Sch\u00e4fer B, Eslam M, Bals R, Janciauskiene S, Carv\u00e3o J, Neureiter D, Zhou B, W\u00f6ran K, Bantel H, Geier A, Dirrichs T, Stickel F, Teumer A, Verbeek J, Nevens F, Govaere O, Krawczyk M, Roskams T, Haybaeck J, Lurje G, Chorostowska-Wynimko J, Genesca J, Reiberger T, Zoller H, Lammert F, Krag A, George J, Anstee QM, Trauner M, Datz C, Gaisa NT, Denk H, Trautwein C, Aigner E, Strnad P: Liver Phenotypes of European Adults Heterozygous or Homozygous for Pi*Z Variant of alpha-1 antitrypsin (Pi*MZ vs Pi*ZZ genotype) and Non-carriers; Gastroenterology 2020 May 3. Pii: S0016-5085(20)30577-1 \u2013 * equal contribution<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fb70532 elementor-widget elementor-widget-button\" data-id=\"fb70532\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"http:\/\/alpha-1global.org\/publication-in-gastroenterology-study-on-liver-involvement-in-mild-alpha-1-antitrypsin-deficiency\/\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Read publication<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Published in \u201cGastroenterology\u201d The Alpha1-Liver Team from Aachen, Germany, which coordinates the European study group for alpha1-antitrypsin deficiency-related liver disease, has published the latest results on liver involvement in mild alpha1-antitrypsin deficiency in the renowned journal Gastroenterology. This work appears a year after the contribution that focused on the liver phenotype in severe alpha1-antitrypsin deficiency [&hellip;]<\/p>\n","protected":false},"author":5,"featured_media":4191,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[62],"tags":[],"class_list":["post-4200","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-others"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Liver Involvement in mild Alpha-1 Antitrypsin Deficiency - Centro Andaluz Alfa-1<\/title>\n<meta name=\"description\" content=\"Involvement in mild Alpha-1 Antitrypsin Deficiency. For the first time, we were able to characterize the extent of liver involvement in carriers of the most relevant alpha1-antitrypsin mutation in two large cohorts resembling the general population.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/centroandaluzalfa1.org\/en\/liver-and-aatd\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Liver Involvement in mild Alpha-1 Antitrypsin Deficiency - Centro Andaluz Alfa-1\" \/>\n<meta property=\"og:description\" content=\"Involvement in mild Alpha-1 Antitrypsin Deficiency. For the first time, we were able to characterize the extent of liver involvement in carriers of the most relevant alpha1-antitrypsin mutation in two large cohorts resembling the general population.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/centroandaluzalfa1.org\/en\/liver-and-aatd\/\" \/>\n<meta property=\"og:site_name\" content=\"Centro Andaluz Alfa-1\" \/>\n<meta property=\"article:published_time\" content=\"2020-07-22T09:53:19+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-07-22T09:59:37+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/centroandaluzalfa1.org\/wp-content\/uploads\/2020\/07\/Gastroenterology.png\" \/>\n\t<meta property=\"og:image:width\" content=\"737\" \/>\n\t<meta property=\"og:image:height\" content=\"313\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Centro Alfa-1 Granada\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@centroalfa1gal\" \/>\n<meta name=\"twitter:site\" content=\"@centroalfa1gal\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Centro Alfa-1 Granada\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/centroandaluzalfa1.org\\\/en\\\/liver-and-aatd\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/centroandaluzalfa1.org\\\/en\\\/liver-and-aatd\\\/\"},\"author\":{\"name\":\"Centro Alfa-1 Granada\",\"@id\":\"https:\\\/\\\/centroandaluzalfa1.org\\\/en\\\/#\\\/schema\\\/person\\\/2e1299ebbb9858082400a9b06d856c52\"},\"headline\":\"Liver Involvement in mild Alpha-1 Antitrypsin Deficiency\",\"datePublished\":\"2020-07-22T09:53:19+00:00\",\"dateModified\":\"2020-07-22T09:59:37+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/centroandaluzalfa1.org\\\/en\\\/liver-and-aatd\\\/\"},\"wordCount\":242,\"publisher\":{\"@id\":\"https:\\\/\\\/centroandaluzalfa1.org\\\/en\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/centroandaluzalfa1.org\\\/en\\\/liver-and-aatd\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/centroandaluzalfa1.org\\\/wp-content\\\/uploads\\\/2020\\\/07\\\/Gastroenterology.png\",\"articleSection\":[\"others\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/centroandaluzalfa1.org\\\/en\\\/liver-and-aatd\\\/\",\"url\":\"https:\\\/\\\/centroandaluzalfa1.org\\\/en\\\/liver-and-aatd\\\/\",\"name\":\"Liver Involvement in mild Alpha-1 Antitrypsin Deficiency - Centro Andaluz Alfa-1\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/centroandaluzalfa1.org\\\/en\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/centroandaluzalfa1.org\\\/en\\\/liver-and-aatd\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/centroandaluzalfa1.org\\\/en\\\/liver-and-aatd\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/centroandaluzalfa1.org\\\/wp-content\\\/uploads\\\/2020\\\/07\\\/Gastroenterology.png\",\"datePublished\":\"2020-07-22T09:53:19+00:00\",\"dateModified\":\"2020-07-22T09:59:37+00:00\",\"description\":\"Involvement in mild Alpha-1 Antitrypsin Deficiency. 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