{"id":4323,"date":"2020-10-13T13:40:13","date_gmt":"2020-10-13T11:40:13","guid":{"rendered":"https:\/\/centroandaluzalfa1.org\/?p=4323"},"modified":"2020-10-13T13:45:33","modified_gmt":"2020-10-13T11:45:33","slug":"the-first-clinical-trial-begins-to-solve-the-folding-of-the-liver-caused-by-protein-z","status":"publish","type":"post","link":"https:\/\/centroandaluzalfa1.org\/en\/the-first-clinical-trial-begins-to-solve-the-folding-of-the-liver-caused-by-protein-z\/","title":{"rendered":"The first clinical trial begins to solve the folding of the liver caused by protein Z"},"content":{"rendered":"\t\t
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The human trial begins, of the treatment that acts on the liver, due to the protein Alpha-1 Antitrypsin.<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Almost all cases of AATD are caused by a single mutation in the A1AT gene, known as the ‘Z mutation’.<\/b><\/span><\/p>

Z Factor, the Cambridge-based drug development company, has administered the first human volunteer ZF874, their novel treatment for alpha-1-antitrypsin deficiency. (AATD).<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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What about Alpha 1 protein?<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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AATD, a genetic disorder, is the lack of a protein made by the liver that is released into the bloodstream. Alpha-1 protein is designed to protect body tissues from attacks by its own enzymes.<\/b><\/p>

\u00a0<\/p>

AATD affects approximately one in 2,000 people in Western countries, where a single flaw in the DNA encoding the alpha-1-antitrypsin (A1AT) protein causes both liver and lung disease.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Causes of the problem<\/i><\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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“The Z mutation” causes most of the A1AT to fold incorrectly, forming polymers that remain in the liver rather than being secreted into the blood, where it plays a key role in protecting the lungs and other organs from damaging effects. of inflammation.<\/p>

\u201cLow levels of correctly folded A1AT in the lungs result in the development of emphysema in almost everyone with AATD. At the same time, the accumulation of Z-A1AT polymers in the liver can cause liver disease, sometimes manifesting as liver failure in newborns and, more commonly, cirrhosis and liver cancer as carriers of this age of mutation. “<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\tRead more<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

The human trial begins, of the treatment that acts on the liver, due to the protein Alpha-1 Antitrypsin. Almost all cases of AATD are caused by a single mutation in the A1AT gene, known as the ‘Z mutation’. Z Factor, the Cambridge-based drug development company, has administered the first human volunteer ZF874, their novel treatment […]<\/p>\n","protected":false},"author":5,"featured_media":2898,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[62],"tags":[],"class_list":["post-4323","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-others"],"yoast_head":"\nThe first clinical trial begins to solve the folding of the liver caused by protein Z - Centro Andaluz Alfa-1<\/title>\n<meta name=\"description\" content=\"Low levels of correctly folded A1AT in the lungs result in the development of emphysema in almost everyone with AATD. 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