{"id":4643,"date":"2021-02-16T16:23:23","date_gmt":"2021-02-16T15:23:23","guid":{"rendered":"https:\/\/centroandaluzalfa1.org\/?p=4643"},"modified":"2021-02-16T16:41:00","modified_gmt":"2021-02-16T15:41:00","slug":"what-is-protein-z","status":"publish","type":"post","link":"https:\/\/centroandaluzalfa1.org\/en\/what-is-protein-z\/","title":{"rendered":"What is protein Z?"},"content":{"rendered":"\t\t
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Z protein is a genetic alteration<\/b><\/span><\/span><\/h3>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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What is Z protein? “Almost all cases of DAAT are caused by a single mutation in the A1AT gene, known as the Z mutation”.<\/h3>

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\u00bfWhat is the function of Z protein?<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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AATD, a genetic disorder that causes the lack of a protein made by the liver, which is released into the bloodstream.<\/p>

This protein is designed to protect body tissues from attacks by its own enzymes.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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What it is said?<\/span><\/strong><\/p>

Almost all cases of DAAT are caused by a single mutation in the A1AT gene, known as\u00a0‘factor<\/a><\/span>\u00a0Z‘.<\/span><\/p>

AATD affects approximately one in every 2,000 people in Western countries. This mutation in the DNA encoding the protein alpha-1-antitrypsin (A1AT) causes both liver and lung disease.<\/i><\/p>

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\u00bfWhat happen in our body?<\/h3>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\u201cThe Z mutation causes most of the A1AT to fold incorrectly, forming polymers that remain in the liver rather than being secreted into the blood, where it plays a key role in protecting the lungs and other organs from the damaging effects of the inflammation.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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How serious is it?<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\u201cLow levels of correctly folded A1AT in the lungs result in the development of emphysema in almost everyone with AATD.<\/p>

At the same time, the accumulation of Z-A1AT polymers in the liver can cause liver disease, sometimes manifesting as liver failure in newborns and, more commonly, cirrhosis and liver cancer as carriers of this age of mutation. “<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\u00bfHow could we improve this situation?<\/h3><\/blockquote>

\u201cUp to a third of all cases of emphysema and cirrhosis could trace the origin of their disease if they knew about this alteration in their DNA.<\/i>\u00a0<\/i><\/p>

A plasma analysis will help you identify this deficiency, this is the proof that science continues to advance until the cure for this rare disease can be discovered.\u00a0<\/p>

For the moment we continue to mitigate its effects, thanks to the discoveries of medicine.<\/b><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\tRead more news<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Protein Z is a genetic alteration “Almost all cases of DAAT are caused by a single mutation in the A1AT gene, known as the Z mutation”. \u00bfWhat is its function? AATD, a genetic disorder that causes the lack of a protein made by the liver, which is released into the bloodstream. This protein is designed […]<\/p>\n","protected":false},"author":5,"featured_media":2902,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[66],"tags":[],"class_list":["post-4643","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-events-aatd"],"yoast_head":"\nWhat is protein Z? - Centro Andaluz Alfa-1<\/title>\n<meta name=\"description\" content=\"What is Z protein? 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