{"id":8104,"date":"2021-11-13T15:01:25","date_gmt":"2021-11-13T14:01:25","guid":{"rendered":"https:\/\/centroandaluzalfa1.org\/?p=8104"},"modified":"2022-02-17T18:42:39","modified_gmt":"2022-02-17T17:42:39","slug":"alpha-1-antitrypsin-deficiency-medical-tests","status":"publish","type":"post","link":"https:\/\/centroandaluzalfa1.org\/en\/alpha-1-antitrypsin-deficiency-medical-tests\/","title":{"rendered":"Alpha 1 Antitrypsin Deficiency Medical Tests"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">Alpha 1 Antitrypsin Deficiency Medical Tests<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">Chest X-ray and TC<\/h3>\n\n\n\n<p>Chest radiography and computed tomography (CT) show diffuse panlobular emphysema predominantly in bases.<\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"alignleft size-large is-resized\"><img fetchpriority=\"high\" decoding=\"async\" src=\"https:\/\/centroandaluzalfa1.org\/wp-content\/uploads\/2021\/11\/twitter-DIAGNosis-1024x576.png\" alt=\"\" class=\"wp-image-8106\" width=\"525\" height=\"296\" srcset=\"https:\/\/centroandaluzalfa1.org\/wp-content\/uploads\/2021\/11\/twitter-DIAGNosis-1024x576.png 1024w, https:\/\/centroandaluzalfa1.org\/wp-content\/uploads\/2021\/11\/twitter-DIAGNosis-300x169.png 300w, https:\/\/centroandaluzalfa1.org\/wp-content\/uploads\/2021\/11\/twitter-DIAGNosis-768x432.png 768w, https:\/\/centroandaluzalfa1.org\/wp-content\/uploads\/2021\/11\/twitter-DIAGNosis-1536x864.png 1536w, https:\/\/centroandaluzalfa1.org\/wp-content\/uploads\/2021\/11\/twitter-DIAGNosis.png 1600w\" sizes=\"(max-width: 525px) 100vw, 525px\" \/><figcaption>    <\/figcaption><\/figure><\/div>\n\n\n\n<p>A quarter of the cases have associated bronchiectasis, a percentage similar to that in the COPD series. Respiratory function can vary, but most have an obstructive pattern with a decrease in FEV and the FEV \/ FVC ratio to more pronounced values \u200b\u200bthan expected by the degree of smoking, and an increase in residual volume, hyperinflation and decrease is observed. of diffusion.<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p><\/p>\n\n\n\n<p><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Bronchodilator test<\/h3>\n\n\n\n<p>In some cases, the patient has a positive bronchodilator test that is sometimes associated with asthma, although the bronchial hyperresponsiveness associated with the ZZ phenotype darkens the prognosis of these patients.<\/p>\n\n\n\n<p>Higher levels of inflammatory markers IL-8 and leukotriene B4 are observed during exacerbations than in COPD exacerbations without AATD, which could explain why exacerbations are frequent and can be more severe and prolonged.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Hepatic disorder in minors<\/h3>\n\n\n\n<p>Some Alpha 1 patients begin their symptoms with a liver disorder in early childhood.<\/p>\n\n\n\n<p>This liver involvement is caused by accumulation of the Z variant of AAT in hepatocytes, although it is not known why only a small proportion of homozygous may experience disease, since in adulthood most patients have normal liver function .<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Panniculitis<\/h3>\n\n\n\n<p>Another more rare clinical form is panniculitis with subcutaneous, erythematous and painful generalized nodules that can be ulcerated. To arrive at a security diagnosis in suspected cases, the steps of an algorithm can be followed.<\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"alignleft size-full\"><img decoding=\"async\" width=\"450\" height=\"605\" src=\"https:\/\/centroandaluzalfa1.org\/wp-content\/uploads\/2021\/11\/clinical-diagnosis-AATD.png\" alt=\"\" class=\"wp-image-8108\" srcset=\"https:\/\/centroandaluzalfa1.org\/wp-content\/uploads\/2021\/11\/clinical-diagnosis-AATD.png 450w, https:\/\/centroandaluzalfa1.org\/wp-content\/uploads\/2021\/11\/clinical-diagnosis-AATD-223x300.png 223w\" sizes=\"(max-width: 450px) 100vw, 450px\" \/><figcaption>   <\/figcaption><\/figure><\/div>\n\n\n\n<p>Diagnostic algorithm for alpha-1-antitrypsin deficiency (AAT).<br>See the diagram for the percentage with respect to the lower limit of the reference interval.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link\" href=\"https:\/\/centroandaluzalfa1.org\/en\/news-on-alpha-1-antitrypsine-deficiency\/\">Read more news<\/a><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Alpha 1 Antitrypsin Deficiency Medical Tests Chest X-ray and TC Chest radiography and computed tomography (CT) show diffuse panlobular emphysema predominantly in bases. A quarter of the cases have associated bronchiectasis, a percentage similar to that in the COPD series. Respiratory function can vary, but most have an obstructive pattern with a decrease in FEV [&hellip;]<\/p>\n","protected":false},"author":5,"featured_media":8106,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[71],"tags":[],"class_list":["post-8104","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-aatd-patients"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - 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