{"id":8210,"date":"2022-02-09T19:06:58","date_gmt":"2022-02-09T18:06:58","guid":{"rendered":"https:\/\/centroandaluzalfa1.org\/?p=8210"},"modified":"2022-03-18T19:35:56","modified_gmt":"2022-03-18T18:35:56","slug":"determination-of-the-serum-concentration-of-aat","status":"publish","type":"post","link":"https:\/\/centroandaluzalfa1.org\/en\/determination-of-the-serum-concentration-of-aat\/","title":{"rendered":"Determination of the serum concentration of AAT"},"content":{"rendered":"\n

How is DAAT serum concentration determined?<\/h2>\n\n\n\n

Determination of serum alpha-1 antitrypsin (AAT) concentration is usually the first step in investigating alpha-1 antitrypsin (AATD) deficiency.<\/h3>\n\n\n\n
\n
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\"\"<\/figure>\n<\/div>\n\n\n\n
\n

The authors of this article analyze the reproducibility of their measurement to assess whether the variability between measurements was associated with markers or reactants of the acute phase of inflammation.<\/p>\n\n\n\n

To do this, they retrospectively analyzed a sample of 255 individuals with chronic obstructive pulmonary disease (COPD) whose serum AAT levels were determined twice, at separate visits<\/p>\n<\/div>\n<\/div>\n\n\n\n

\n
\n

White blood cell count and fibrinogen as markers of inflammation in the acute phase were also measured in the second determination.<\/p>\n<\/div>\n<\/div>\n\n\n\n

Serious AATD<\/h3>\n\n\n\n

In patients with severe AATD, the observed variation in AAT levels from measurement to measurement is unlikely to alter the conclusions. <\/p>\n\n\n\n

The situation is less clear in patients with intermediate DAAT, in whom borderline and even normal AAT levels are often found.<\/p>\n\n\n\n

They finally concluded that although the 2 serum AAT levels were significantly correlated, the agreement was weak with wide limits on AAT concentrations.<\/p>\n\n\n\n

Considering that serum concentrations of AAT below 1.13 g\/L justify the initiation of further investigations to confirm DAAT, discrepancies between test-retest AAT levels led to reevaluation of 22% of patients wrongly classified.<\/strong><\/p>\n\n\n\n

This is not an assumption, considering that many studies have shown that the MZ and SZ genotypes confer a significantly increased risk of COPD in smokers.<\/p>\n\n\n\n

Serum concentration variation<\/strong><\/h4>\n\n\n\n

AAT is synthesized and secreted primarily by hepatocytes (\u226580%), and in additional amounts by monocytes, macrophages, alpha and delta cells of the pancreas, type II alveolar epithelial cells of the lung, enterocytes, and other cells.<\/p>\n\n\n\n

Being an acute phase reactant, plasma concentrations of AAT increase rapidly 2-3 times in response to inflammatory or infectious stimuli, accompanying C-reactive protein (CRP) and amyloid A, and this increase is maintained from 7- 15 days.<\/p>\n\n\n\n

For this reason, the determination of the serum concentration of AAT will be carried out under basal conditions and it is advisable to measure the CRP.<\/strong><\/p>\n\n\n\n

Therefore, the importance of accurate determination of serum AAT concentration for COPD risk stratification, as well as for counseling purposes, even in intermediate deficiency, is clear.<\/p>\n\n\n\n

Concordance in AAT level has relevance to the underlying genotype: the proportion of patients carrying 1 or 2 deficiency alleles was higher in those with 2 concordant AAT levels <1.13 g\/l compared with those with discordant results .<\/p>\n\n\n\n

Based on articles<\/a> found in these webs.<\/p>\n\n\n\n

https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8686854\/<\/a><\/p>\n\n\n\n

https:\/\/journal.copdfoundation.org\/Portals\/0\/JCOPDF\/Files\/Volume8-Issue4\/JCOPDF-2021-0228-Haillot.pdf<\/a><\/p>\n\n\n\n

https:\/\/erj.ersjournals.com\/content\/50\/5\/1700610<\/a><\/p>\n\n\n\n

\n
Read more news<\/a><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Determination of serum alpha-1 antitrypsin (AAT) concentration is usually the first step in investigating alpha-1 antitrypsin (AATD) deficiency.<\/p>\n","protected":false},"author":5,"featured_media":8273,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[71,64],"tags":[86,89,87,84,88],"class_list":["post-8210","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-aatd-patients","category-aatd-up-to-date","tag-alpha-1","tag-alpha-1-deficiency","tag-medicine","tag-rare-disease","tag-research"],"yoast_head":"\nDetermination of the serum concentration of AAT - 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