{"id":8245,"date":"2022-02-17T18:38:22","date_gmt":"2022-02-17T17:38:22","guid":{"rendered":"https:\/\/centroandaluzalfa1.org\/?p=8245"},"modified":"2022-02-17T18:40:39","modified_gmt":"2022-02-17T17:40:39","slug":"aatd-diagnosis-and-treatment","status":"publish","type":"post","link":"https:\/\/centroandaluzalfa1.org\/en\/aatd-diagnosis-and-treatment\/","title":{"rendered":"AATD diagnosis and treatment"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\" id=\"aatd-diagnosis-and-treatment\">AATD diagnosis and treatment<\/h2>\n\n\n\n<p><\/p>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:66.66%\">\n<figure class=\"wp-block-image size-large is-style-default\"><img decoding=\"async\" src=\"https:\/\/centroandaluzalfa1.org\/wp-content\/uploads\/2022\/02\/Diagnostico-y-tratamiento-del-deficit-del-DAAT-HUSC-y-Centro-Andaluz-alfa-1-e1645117688701.jpeg\" alt=\"Diagn\u00f3stico y tratamiento del d\u00e9ficit del DAAT\" class=\"wp-image-8235\"\/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.33%\">\n<p>On Monday, February 14, GSK organized the Kon\u00e9ctate event.<\/p>\n\n\n\n<p>Pulmonology professionals from all over Spain were able to spread their knowledge in a clinical session that took place in the<a href=\"https:\/\/www.husc.es\/\" target=\"_blank\" rel=\"noreferrer noopener\"> San Cecilio University Hospital<\/a>, HUSC.<\/p>\n\n\n\n<p>In this event, Phd. Francisco Casas, a specialist pulmonologist, gave a presentation on AATD.<\/p>\n\n\n\n<p>Furthermore, Pneumology specialists from another 38 hospitals throughout Spain participated.<\/p>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"what-is-alpha-1-antitripsine\">What is Alpha 1 Antitripsine?<\/h2>\n\n\n\n<p>Alpha-1 antitrypsin (AAT) is a glycoprotein of the serpin family secreted mainly by the liver. <\/p>\n\n\n\n<p>Therefore, it is the most abundant protease inhibitor in human serum and its specific target is neutrophil elastase, a voracious protease capable of digesting elastin, basement membranes and other components of the extracellular matrix. <\/p>\n\n\n\n<p><strong>In addition, it has antioxidant, anti-inflammatory, antimicrobial and immunomodulatory properties that have currently gained great relevance due to its possible application in the treatment of SARS-CoV-2 coronavirus infection (COVID-19).<\/strong><\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"the-rare-disease-alpha-1-antitrypsin\">The rare disease Alpha 1 Antitrypsin<\/h3>\n\n\n\n<p>Alpha-1 antitrypsin deficiency (DAAT) is a congenital disease that causes low serum levels of AAT and predisposes to the development of chronic obstructive pulmonary disease (COPD), pulmonary emphysema, and in some cases also liver disease. <\/p>\n\n\n\n<p><strong>So, it is a very underdiagnosed disease since less than 10% of patients with severe alpha-1 antitrypsin deficiency (DAAT) are diagnosed. <\/strong><\/p>\n\n\n\n<p>Besides, until the patient is diagnosed with AATD, an average of 7-10 years usually elapse when they arrive at a consultation with an average of 5 doctors without ever determining the concentration of AAT in their blood. <\/p>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"for-this-reason-the-world-health-organization-who-and-the-main-scientific-societies-of-pulmonology-recommend-requesting-its-determination-to-all-patients-with-copd-once-in-their-lives\">For this reason, the World Health Organization (WHO) and the main Scientific Societies of Pulmonology recommend requesting its determination to all patients with COPD once in their lives.<\/h4>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"diagnosis-and-treatment-of-daat-deficiency\">Diagnosis and treatment of DAAT deficiency<\/h3>\n\n\n\n<p>We currently have diagnostic tools that have been incorporated into a novel diagnostic algorithm that we present.<\/p>\n\n\n\n<p>In conclusion, patients with severe AATD and COPD must be treated according to the Clinical Practice Guidelines.<\/p>\n\n\n\n<p>In addition, we must assess the criteria for starting treatment with intravenous AAT, recommending its control and follow-up in Units or Centers of Excellence in Alpha-1. <\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"centro-andaluz-alfa-1\">Centro Andaluz Alfa 1<\/h3>\n\n\n\n<p>The Andalusian Center Alfa-1 of Granada is structured as a Multidisciplinary Unit in which Digestive (Hepatology Unit), Paediatrics, Rehabilitation and Nursing (Medical Day Hospital) participate, it is accredited by the Spanish Society of Pulmonology and Thoracic Surgery (SEPAR ) with the level of \u201cExcellence\u201d and cares for about 50 patients with AATD.<\/p>\n\n\n\n<p>To resume, In this session, a brief historical review of DAAT has been carried out with the most representative milestones of the last 20 years.<\/p>\n\n\n\n<p><strong>The new diagnostic algorithm has been presented, the treatment has been updated and the therapeutic perspectives under development have been reviewed.<\/strong><\/p>\n\n\n\n<p>MODERATOR: Dr. Manuel Gallardo Medina. Head of the Pneumology Clinical Management Unit of the San Cecilio Clinical University Hospital in Granada.<\/p>\n\n\n\n<p>SPEAKER: Dr. Francisco Casas Maldonado. Coordinator of the Andalusian Center Alfa-1 of Granada.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link\" href=\"https:\/\/centroandaluzalfa1.org\/en\/news-on-alpha-1-antitrypsine-deficiency\/\">Read more news<\/a><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>AATD diagnosis and treatment On Monday, February 14, GSK organized the Kon\u00e9ctate event. Pulmonology professionals from all over Spain were able to spread their knowledge in a clinical session that took place in the San Cecilio University Hospital, HUSC. In this event, Phd. Francisco Casas, a specialist pulmonologist, gave a presentation on AATD. Furthermore, Pneumology [&hellip;]<\/p>\n","protected":false},"author":5,"featured_media":8239,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[66],"tags":[85,89,93,91,90,92,94],"class_list":["post-8245","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-events-aatd","tag-aatd-2","tag-alpha-1-deficiency","tag-doctor","tag-medical-event","tag-patients","tag-phd","tag-pneumology"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - 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