Welcome to the Centro Andaluz 
 Alpha-1 Antitrypsin Deficiency of Granada

Our commitment is to promote research and training in Alpha-1 Antitrypsin Deficiency

Alpha-1 antitrypsin deficiency (AATD) is characterized by abnormally low concentrations of alpha-1 antitrypsin (AAT) in plasma and is one of the best-known and most frequent genetic causes that, in its severe forms, predisposes to the development of Chronic Obstructive Pulmonary Disease (COPD), emphysema, or liver disease. It is estimated that in Spain there may be around 12,000 individuals with the severe homozygous deficit Pi*ZZ.

Despite this well-known relationship, COPD secondary to AATD continues to be a challenge as it is a disease with a high underdiagnosis due to its low clinical suspicion. Other challenges consist of generating knowledge about the disease, mechanisms research possibilities and new therapies. 

Its minority respiratory disease condition makes it necessary to concentrate the cases detected in Centers of Excellence in AATD with the aim of generating knowledge about the disease and developing lines of research.

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Our team

The institution that started the treatment of this pathology, a pioneer in developing a case detection program and treatment with intravenous AAT, was the Vall d’Hebron University Hospital in Catalonia, whose center of excellence in AATD is coordinated by Dr. Marc Miravitlles since 2014.

In Andalusia, the pioneering institution has been the San Cecilio Clinical University Hospital of Granada. Dr. Francisco Casas has directed this Center of Excellence since its creation in May 2016, and is recognized by the Spanish Society of Pneumology and Thoracic Surgery (SEPAR).

Galicia has the Galician Alpha-1 Center since 2017, coordinated by Dr. María Torres, and since 2018 Andalusia also has the Seville Center of Excellence in AATD, coordinated by Dr. José Luis López-Campos.

Our mission


Provide personalized health care for patients and offer information to their families.


Undertake clinical studies to understand the evolution of the disease and its impact on the quality of life of patients and their families.


Promote training and awareness of AATD among health professionals and medical students.

Organize conferences and courses on progress and discovery updates.


Conduct outreach activities about the disease to patients and their families. 


Our mission is to improve the health and well-being of patients around the world. One of our strategic objectives is to define lines of research on the disease in order to improve patient health care. Here you will find news, publications and articles related to the most recent advances.

In search of the cure

We are committed to sustainable growth that makes a positive impact on AATD

Together we will achieve better results
There are many scientific societies, institutions and patient associations, nationally and internationally, interested in research to find treatment for the cure. Read more information of interest about the AATD.

Contact us

For further information, you could contact us via e-mail, telephone or via the form